Agent Orange Presumptive Conditions: Full List and How to File

Agent Orange is a herbicide used extensively during the Vietnam War and at other locations during the late Cold War period. The VA presumes service connection for veterans with qualifying service who develop any of the listed conditions, meaning you do not need to prove that Agent Orange caused your condition. You need only show that you were exposed and that you have the diagnosis.

Who has qualifying exposure

Veterans who served in Vietnam between January 9, 1962 and May 7, 1975 and set foot in country or served on inland waterways have presumptive exposure. The PACT Act expanded this to include veterans who served in the territorial waters of Vietnam.

Veterans who served in Korea in the Korean Demilitarized Zone between September 1, 1967 and August 31, 1971 have presumptive Agent Orange exposure.

Veterans who performed testing or storage of Agent Orange at Johnston Atoll or aboard ships that transported it qualify.

The PACT Act also created a category for Blue Water Navy veterans who served in the offshore waters of Vietnam, significantly expanding who qualifies.

Current presumptive conditions

The VA regularly updates the presumptive list. As of 2026, the following conditions are presumptive for veterans with qualifying Agent Orange exposure:

Cancers: AL amyloidosis, bladder cancer, chronic B-cell leukemias including hairy cell leukemia, Hodgkin disease, multiple myeloma, non-Hodgkin lymphoma, prostate cancer, respiratory cancers of the lung, bronchus, larynx, and trachea, soft-tissue sarcomas (other than osteosarcoma, chondrosarcoma, Kaposi sarcoma, or mesothelioma).

Other conditions: chloracne or other acneform disease, diabetes mellitus type 2, hypothyroidism, ischemic heart disease, monoclonal gammopathy of undetermined significance, Parkinson disease and Parkinsonism, peripheral neuropathy (early-onset), porphyria cutanea tarda.

The PACT Act added hypertension and monoclonal gammopathy as presumptive conditions for veterans with certain toxic exposure histories including Agent Orange exposure.

How to file

File VA Form 21-526EZ. In the condition section, identify the specific diagnosis and note that it is a claimed Agent Orange presumptive. Include your DD-214 showing qualifying service dates and locations, and medical evidence documenting your current diagnosis.

You do not need a nexus letter for presumptive conditions. The VA presumes the connection based on your service and diagnosis. The claim is stronger with current medical records documenting the diagnosis and its severity.

Veterans who were previously denied Agent Orange claims before the presumptive list was expanded may be able to reopen those claims if their condition is now on the list.

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Bill Advantage is a document literacy tool. Nothing in this article constitutes legal or medical advice.